In vitro characterization of hydroxyapatite and cobalt ferrite nanoparticles compounds and their biocompatibility in vivo

• DOI: 10.1007/s10856-022-06640-z
• Publication Date: 2022-02-07T13:03:44Z
• Authors: Cristiane C. Vita...; Dayana A. C. Ferr...; Fabrícia H. Loures; Pascally M. A. G....; Iara M. Ribeiro; Fabiana R. Araújo; Fabrício L. Valente; Emily C. Carlo Reis; Ana Cristina F. M...; Sheila M. C. M. B...; Andréa P. B. Borges
• Keywords: Biocompatibility; Biomaterial

Bioactive materials in combination with antibiotics have been widely developed for the treatment of bone infection. Thus, this work aims to characterize six biomaterials formulated different concentrations hydroxyapatite and cobalt ferrite nanoparticles, addition antibiotic ciprofloxacin, using X-ray diffraction (XRD), scanning electron microscopy (SEM), diffusion test on agar. Furthermore, vivo biocompatibility reabsorption process these were analyzed. XRD showed that both present high crystallinity. The photomicrographs obtained by SEM revealed composites a complex surface, evidenced irregular arrangement granules, besides demonstrating interaction between their components. antibiotic-diffusion all produced an inhibition halo Staphylococcus aureus cultures. For study, surgically implanted dorsal region rabbits. At 15, 30, 70, 100 days, biopsies regions performed. easily identified during histological analysis no significant inflammatory process, nor signs toxicity or rejection adjacent tissue observed. We can conclude analyzed are biocompatible, degradable, effective inhibiting vitro growth aureus. Graphical abstract.