Three-dimensional printed calcium phosphate scaffolds emulate bone microstructure to promote bone regrowth and repair

• DOI: 10.1007/s10856-024-06817-8
• Publication Date: 2024-09-03T12:02:16Z
• Authors: Kyohei Takase; Takahiro Niikura; Tomoaki Fukui; Yohei Kumabe; Kenichi Sawauchi; Ryo Yoshikawa; Yuya Yamamoto; Ryota Nishida; Tomoyuki Matsumoto; Ryosuke Kuroda; Keisuke Oe
• Keywords: 3d printed; Bone tissue; Bone Growth; Bone remodeling; Bone Formation

Abstract The interconnected structures in a 3D scaffold allows the movement of cells and nutrients. Therefore, this study aimed to investigate in-vivo bioactivity 3D-printed β-tricalcium phosphate (β-TCP) hydroxyapatite (HAP) scaffolds that replicate biological bone. This included 24-week-old male New Zealand white rabbits. A cylindrical bone defect with diameter 4.5 mm depth 8 was created lateral aspect distal femur. implanted right femur (experimental side), whereas left kept free implantation (control side). Micro-CT analysis histological observations site were conducted at 4, 8, 12 weeks postoperatively track repair progress. No evidence new tissue formation found medullary cavity on control side. In contrast, experimental side, demonstrated sufficient bioactivity, leading growth tissue. Over time, gradually extended from periphery toward center, phenomenon evident both micro-CT images biopsy staining. current study, we observed involved metabolism adhered, spread, proliferated our newly designed microstructure. it is suggested has induce could be expected more useful artificial than existing version. Graphical