Low-grade inflammation may moderate the effect of behavioral treatment for chronic pain in adults

• DOI: 10.1007/s10865-016-9769-z
• Publication Date: 2016-07-28T04:26:35Z
• Authors: Julie Lasselin; Mike K. Kemani; Marie Kanstrup; Gunnar L. Olsson; John Axelsson; Anna Andreasson; Mats Lekander; Rikard K. Wicksell
• Keywords: Health psychology; Basal (medicine)

The purpose of the present pilot study was to explore moderating role basal inflammation on effects behavioral pain treatment in 41 patients with long-standing pain. Baseline pro-inflammatory status moderated outcomes: higher pre-treatment levels Tumor Necrosis Factor (TNF)-α and Interleukin (IL)-6 were related less improvement intensity, psychological inflexibility mental health-related quality life. outcomes improved subgroup that had low cytokines at baseline, while subjects did not. Altogether, results indicate low-grade may influence provide a possible explanation heterogeneity response.