Synthesis and Structural Characterization of (2,4-Diamino-5-(3′,4′,5′-Trimethoxybenzyl)Pyrimidine Copper (II)) Complex

• DOI: 10.1007/s10870-009-9545-9
• Publication Date: 2009-03-31T13:58:03Z
• Authors: Uzma Habib; Amin Badshah; Ulrich Flörke; Rizwana Aleem Qur...; Bushra Mirza; Nazar-ul-Islam; Azeem Khan
• Keywords: Triclinic crystal system; Organometallic Chemistry; Trimethoprim; Derivative (finance)

The reaction of Cu(OOCCH3)2·H2O with (2,4-diamino-5-(3′,4′,5′-trimethoxybenzyl) pyrimidine (trimethoprim) in ethanolic solution at 80 °C affords the title complex which has been characterized by elemental, IR, and NMR (1H and 13C).The crystal structure has been determined by single crystal X-ray diffraction. Compound 1 (C36H48Cu2N8O14) is triclinic, space group P-1 with a = 7.2676(4) A, b = 11.6721(7) A, c = 12.8279(8) A, α = 95.839(1)°, β = 93.456(1)°, γ = 105.541(1)°, Z = 1. Two copper atoms are coordinated directly to each other as well as are held together by four bridging aceto groups. Each copper atom is also bonded opposite the Cu–Cu vector to a trimethoprim molecule through the N(1) atom of the pyrimidine ring. Trimethoprim acts as a monodentate ligand through the pyrimidine nitrogen N(1) atom. The complex was screened for the activity against several bacteria, showing more activity against bacteria as compared to trimethoprim. To enhance the activity of trimethoprim, its derivative was prepared and there bacterial activity against several bacteria was analyzed.