The Influence of Polymorphisms of Interleukin-17A and Interleukin-17F Genes on the Susceptibility to Ulcerative Colitis

• DOI: 10.1007/s10875-007-9125-8
• Publication Date: 2007-09-08T11:53:29Z
• Authors: Tomiyasu Arisawa; Tomomitsu Tahara; Tomoyuki Shibata; Mitsuo Nagasaka; Masakatsu Nakamura; Yoshio Kamiya; Hiroshi Fujita; Masahiko Nakamura; Daisuke Yoshioka; Yuko Arima; Masaaki Okubo; Ichiro Hirata; Hiroshi Nakano
• Keywords: Adult; Male; 0301 basic medicine; Polymorphism, Genetic; Genotype; Interleukin-17; Middle Aged; 3. Good health; 03 medical and health sciences; Gene Frequency; Humans; Colitis, Ulcerative; Female; Genetic Predisposition to Disease; Alleles; Aged

We investigated the association between ulcerative colitis (UC) and polymorphisms of IL-17A (rs2275913, G-197A) and IL-17F (rs763780, 7488T/C) genes. We employed the multiplex PCR-SSCP method to detect gene polymorphisms. Both the numbers of -197A (IL-17A) and 7488T (IL-17F) alleles were significantly correlated to the development of UC. The frequencies of -197A/A and 7488T/T genotypes in the UC group were significantly higher than those in the non-UC group. An adjusted analysis revealed that -197A and 7488T alleles were independent risk factors for the developing UC. In addition, both polymorphisms were significantly associated with the pancolitis phenotype. Furthermore, -197A allele was significantly correlated to the chronic relapsing phenotype and -197A/A homozygote was more frequent in steroid-dependent cases, whereas 7488T allele was correlated with the chronic continuous phenotype. Our results provided the first evidence that -197A (IL-17A) and 7488T (IL-17F) alleles may influence the susceptibility to and pathophysiological features of UC independently.