The 2017 IUIS Phenotypic Classification for Primary Immunodeficiencies

• DOI: 10.1007/s10875-017-0465-8
• Publication Date: 2017-12-11T02:25:43Z
• Authors: Aziz Bousfiha; Leïla Jeddane; Capucine Picard; Fatima Ailal; H. Bobby Gaspar; Waleed Al-Herz; Talal Chatila; Yanick J. Crow; Charlotte Cunning...; Amos Etzioni; Jose Luis Franco; Steven M. Holland; Christoph Klein; Tomohiro Morio; Hans D. Ochs; Eric Oksenhendler; Jennifer Puck; Mimi L. K. Tang; Stuart G. Tangye; Troy R. Torgerson; Jean-Laurent Casa...; Kathleen E. Sullivan
• Keywords: Immunologic Deficiency Syndromes

Since the 1990s, International Union of Immunological Societies (IUIS) PID expert committee (EC), now called Inborn Errors Immunity Committee, has published every other year a classification inborn errors immunity. This complete catalog serves as reference for immunologists and researchers worldwide. However, it was unadapted clinicians at bedside. For those, IUIS EC is publishing phenotypical since 2013, which proved to be more user-friendly. There are 320 single-gene immunity underlying phenotypes diverse infection, malignancy, allergy, auto-immunity, auto-inflammation. We herein propose revised 2017 phenotypic classification, based on accompanying Committee classification.