On the role of specific drug binding in modelling arterial eluting stents

• DOI: 10.1007/s10910-016-0618-7
• Publication Date: 2016-03-08T11:01:34Z
• Authors: Sean McGinty; Giuseppe Pontrelli
• Keywords: Arterial wall

In this paper we consider drug binding in the arterial wall following delivery by a drug-eluting stent. Whilst it is now generally accepted that non-linear saturable reversible model required to properly describe process, precise form of varies between authors. Our particular interest manuscript assessing what extent modelling specific and non-specific as separate phases important. We study issue extending recently developed coupled release tissue distribution, comparing simulated profiles concentration mass each phase within tissue.