Novel pH-Sensitive Hydrogel Beads Based on Carrageenan and Fish Scale Collagen for Allopurinol Drug Delivery

• DOI: 10.1007/s10924-020-01727-6
• Publication Date: 2020-04-07T21:12:40Z
• Authors: Chinh Thuy Nguyen; Manh Quoc Vu; Thuy Thi Phan; Trung Quoc Vu; Quan An Vo; Giang Long Bach; Hoang Thai
• Keywords: Allopurinol; Carrageenan

In this work, pH-sensitive hydrogel beads based on fish scale collagen and carrageenan were used as a novel allopurinol drug loading system to improve the bioavailability of allopurinol, which is used to treat gout and high levels of uric acid in the human body. The effectiveness of the carrageenan/collagen/allopurinol hydrogel beads in improving the physical properties of allopurinol and the ability for drug release control in different simulated body fluids were evaluated by infrared (IR) spectroscopy, field emission scanning electron microscopy (FESEM), differential scanning calorimetry (DSC), dynamic light scattering (DLS) and Ultraviolet–Vis (UV–Vis) spectroscopy. In addition, the ability of hydrogen bond formation between allopurinol, carrageenan and collagen was calculated theoretically based on the B3LYP/6-31+g(d)//B3LYP/6-311++g(d,p) level of theory. Both the theoretical and experimental results proved that the hydrogen bonds of the functional groups in allopurinol with the functional groups in carrageenan and fish scale collagen contributed to the enhancement of drug release control as well as to the bioavailability of allopurinol loaded into the carrageenan/collagen hydrogel beads. The dissolution of carrageenan/collagen/allopurinol hydrogel beads in different simulated body fluids increased by 1.6 to 6.7 times compared to that of crystalline allopurinol.