Time and cost effective production of sodium [18F]fluoride using a dedicated automation module with disposable cassettes for GMP environment

• DOI: 10.1007/s10967-016-4709-5
• Publication Date: 2016-02-22T05:55:35Z
• Authors: Jae Yong Choi; Ji Woong Lee; Kyo Chul Lee; Kyeong Min Kim; Youngbeom Seo; Jung Young Kim; Young Hoon Ryu
• Keywords: Positron emission tomography; 03 medical and health sciences; 0302 clinical medicine; Sodium [18F]fluoride; Bone scintigraphy

The aim of the present study is to establish a time and cost effective Na[18F]F preparation method. The process is composed of absorbing radioactive impurities with cation exchange cartridge (CM), trapping 18F-fluroide with QMA cartridges, and formulating the product. The total preparation time determined at the end of bombardment was 4 min and the radiochemical yield was 82 % (n = 29). The final formulated Na[18F]F solution satisfies the USP criteria for quality control.