Colostral Proline-Rich Polypeptide Complexes. Comparative Study of the Antioxidant Properties, Cytokine-Inducing Activity, and Nitric Oxide Release of Preparations Produced by a Laboratory and a Large-Scale Method

• DOI: 10.1007/s10989-019-09876-6
• Publication Date: 2019-06-22T05:25:27Z
• Authors: Agnieszka Zabłocka; Agata Sokołowska; Józefa Macała; Magdalena Bartosz...; Małgorzata Mitkie...; Maria Janusz; Tadeusz Wilusz; Antoni Polanowski
• Keywords: 0301 basic medicine; 03 medical and health sciences; 3. Good health

Colostral proline-rich polypeptide complex (PRP) with immunoregulatory and procognitive activities shows beneficial effects in Alzheimer's disease (AD). As the laboratory method of isolating PRP is expensive, laborious, time consuming, a new large-scale methanol isolation was developed. The obtained by this (named PRP–MPRP) from both ovine or bovine colostra psychotropic activity inhibitory effect on amyloid β aggregation similar to those produced laboratory-scale method. comparative study antioxidant properties, cytokine-inducing activity, nitric oxide release MPRP showed that preparations are biologically active, moreover should be used at concentration higher than 100 µg/ml obtain results comparable PRP.