Efficient induction of apoptosis by proteasome inhibitor: bortezomib in the human breast cancer cell line MDA-MB-231

• DOI: 10.1007/s11010-013-1939-5
• Publication Date: 2014-01-02T15:48:33Z
• Authors: Rafał Krętowski; Małgorzata Borzym...; Marzanna Cechowsk...
• Keywords: 0301 basic medicine; Proteasome Endopeptidase Complex; Cell Survival; Clinical Biochemistry; Antineoplastic Agents; Apoptosis; Breast Neoplasms; Cell Biology; Fibroblasts; beta-Galactosidase; Boronic Acids; Article; Cell Line; 3. Good health; Bortezomib; 03 medical and health sciences; Cell Line, Tumor; Pyrazines; Humans; Female; HSP70 Heat-Shock Proteins; Hypoxia; Molecular Biology; Proteasome Inhibitors

The cellular and molecular effects of the proteasome inhibitor-bortezomib-on breast cancer cells are as yet poorly characterised. Bortezomib selectively induces apoptosis in some cells. However, nature its selectivity remains unknown. Previously, we demonstrated that: there was no effect bortezomib action on a time-dependent increase senescence human skin fibroblasts. study presented here provides novel information line MDA-MB-231. Our findings that contrast to normal fibroblasts, treatment evoked strong incubated hypoxic normoxic conditions. We observed up 70 % MDA-MB-231 There these suggest may be candidates for further evaluation chemotherapeutic agents cancer.