Alternative new mesenchymal stem cell source exerts tumor tropism through ALCAM and N-cadherin via regulation of microRNA-192 and -218

• DOI: 10.1007/s11010-016-2909-5
• Publication Date: 2016-12-30T10:37:47Z
• Authors: Ran Kim; Sang In Park; Chang Youn Lee; Jihyun Lee; Pilseog Kim; Sekyung Oh; Hojin Lee; Min Young Lee; Jongmin Kim; Yong-An Chung; Ki-Chul Hwang; Lee-So Maeng; Woochul Chang
• Keywords: ALCAM; Homing (biology)

Gliomas are the most common type of malignant primary brain tumors. Some treatments gliomas exist, but they rarely curative. Mesenchymal stem cells (MSCs) emerging as potential modes targeted cancer therapy owing to their capacity for homing toward tumor sites. It has been proposed that MSCs derived from various sources, such bone marrow, adipose tissue and umbilical cord blood, can be used cell-based Here, obtained synovial fluid osteoarthritis or rheumatoid arthritis patients were investigated therapeutic candidates. Specifically, we compared migratory adhesive abilities, well expression levels related genes microRNA in marrow derived-MSCs (BMMSCs), (ADMSCs), (SFMSCs) after treatment with conditioned medium gliomas. Migration adhesion SFMSCs increased through upregulation activated lymphocyte cell molecule (ALCAM) N-cadherin by microRNA-192 -218 downregulation, similar BMMSCs ADMSCs. Migratory capacities all types evaluated vivo, migrated intensively These results suggest have use antitumor therapies.