Lichen-derived caperatic acid and physodic acid inhibit Wnt signaling in colorectal cancer cells

• DOI: 10.1007/s11010-017-3178-7
• Publication Date: 2017-09-11T14:27:46Z
• Authors: Jarosław Paluszczak; Robert Kleszcz; Elżbieta Studzińs...; Violetta Krajka-K...
• Keywords: AXIN2; Survivin

Lichens are a source of secondary metabolites which possess important biological activities, including antioxidant, antibacterial, anti-inflammatory, and cytotoxic effects. The anticancer activity lichens was shown in many types tumors, colorectal cancers (CRC). Several studies revealed that the application lichen extracts diminished proliferation CRC cells induced apoptosis. Colon carcinogenesis is associated with aberrations Wnt signaling. Elevated transcriptional β-catenin induces cell survival, proliferation, migration. Thus, inhibition signaling promising therapeutic strategy cancer. aim this study evaluation effects lichen-derived depsides (atranorin, lecanoric acid, squamatic acid) depsidones (physodic salazinic poly-carboxylic fatty acid—caperatic on HCT116 DLD-1 cancer lines. were more sensitive to modulatory compounds. PKF118-310, used as reference inhibitor, dose-dependently reduced expression classical target gene—Axin2 both Lecanoric acid slightly Axin2 while caperatic tended reduce Physodic much potently decreased than cells. also survivin MMP7 line time-dependent manner. None compounds affected nuclear translocation β-catenin. This first report showing ability physodic modulate β-catenin-dependent transcription.