Portosystemic Hepatic Encephalopathy Scores (PHES) differ between Danish and German healthy populations despite their geographical and cultural similarities

• DOI: 10.1007/s11011-024-01380-1
• Publication Date: 2024-07-17T09:01:55Z
• Authors: Mette Munk Lauridsen; Lea Ladegaard Grø...; Jeppe Holm Atkins; Stine Ulrik Mikke...; Tintin Svensson; Nina Kimer; Hartmut Hecker; Gabriele Berg-Bec...; Karin Weissenborn; Hendrik Vilstrup
• Keywords: Danish; Hepatic Encephalopathy

Minimal hepatic encephalopathy (MHE) is common in liver cirrhosis and identified by psychometric tests. The portosystemic score (PHES) the most widely used serves as an inter-study comparator. PHES has not been standardised for use Danish population, where German normal values have applied until now based on notion that populations are comparable. This study aimed to evaluate if can be population establish needed. 200 217 healthy persons underwent Number Connection Test A B (NCT), Line Tracing (LTT), Digit Symbol (DST), Serial Dotting (SDT), performance, was calculated. performance declined with age all subtests but more rapidly Danes. Both norms were impacted gender education, a different extent single tests of test battery. Accordingly, there need specific values, which presented here. Applying new instead patients yielded lower percentage out-of-norm performances (58% vs. 66%) and, hence, prevalence MHE. Danes Germans perform differently PHES, therefore, cannot patients. here yield number 'out norm' performances.