Water transport and absorption in pharmaceutical tablets – a numerical study

• DOI: 10.1007/s11012-019-01103-2
• Publication Date: 2019-12-16T17:45:39Z
• Authors: Povilas Vaitukaitis; Dario Maggiolo; Johan Remmelgas; Susanna Abrahmsén...; Diana Bernin; Maria Siiskonen; Johan Malmqvist; Srdjan Sasic; Gaetano Sardina
• Keywords: Lattice Boltzmann methods; Penetration (warfare)

Abstract The quality of a coated pharmaceutical tablet can be strongly affected by the interactions water droplets with porous substrate during processes such as coating process. Three different mechanisms co-exist in process: spreading, absorption and evaporation. Disentangling fundamental understanding these phenomena therefore crucial for achieving higher products (e.g. longer shelf-life tablets) controlling efficiency This paper aims to investigate spreading after droplet impingement on using Lattice-Boltzmann methodology. Our numerical results (droplet height penetration depth absorbed volume) are good agreement experimental data simulations available literature. In particular, phase is characterised capillary time scale, confirmed previous studies. contrast studies, we find that process begins at times shorter than but power-law volume. We explain this behaviour through modified Washburn law takes into account three-dimensional effects. used benchmark test novel mathematical models.