Synthesis of isoflavones by room-temperature nickel-catalyzed cross-couplings of 3-iodo(bromo)chromones with arylzincs

• DOI: 10.1007/s11030-013-9495-1
• Publication Date: 2014-01-28T05:23:34Z
• Authors: Zunting Zhang; Jinfeng Qiao; Ding Wang; Ling Han; Ru Ding
• Keywords: Negishi coupling

A new concise, facile method for synthesis of isoflavones was accomplished in moderate to good yields for 3-iodochromones or 3-bromochromones and arylzinc bromides via Negishi cross-coupling reaction catalyzed by NiCl(2)/PPh(3) or NiCl(2)(PPh(3))(2) at room temperature. The Isoflavone core was synthesized in four steps in good yield, starting from commercially available 2-hydroxyacetophenone and aromatic bromide. Three steps of the procedure were carried out at room temperature.