Prognostic impact of Metadherin–SND1 interaction in colon cancer

• DOI: 10.1007/s11033-012-1933-0
• Publication Date: 2012-10-17T20:14:44Z
• Authors: Nan Wang; Xilin Du; Li Zang; Nuan Song; Tao Yang; Rui Dong; Tao Wu; Xianli He; Jianguo Lu
• Keywords: Male; 0303 health sciences; Colon; Membrane Proteins; Nuclear Proteins; RNA-Binding Proteins; Kaplan-Meier Estimate; Middle Aged; Endonucleases; Prognosis; Immunohistochemistry; 3. Good health; 03 medical and health sciences; Antibody Specificity; Colonic Neoplasms; Multivariate Analysis; Humans; Female; Cell Adhesion Molecules; Aged; Protein Binding

The interaction between Metadherin (MTDH) and Staphylococcal nuclease homology domain containing 1 (SND1) is involved in tumorigenesis and tumor progression of several human malignancies. However, its roles in colon cancer are still unclear. To investigate the clinical value of MTDH and SND1 expression in colon cancer. Immunohistochemical staining was performed to detect the expression of MTDH and SND1 using human colon cancer and their corresponding non-cancerous colon tissues from 196 patients' biopsies. Positive expression of MTDH and SND1 were both increased in colon cancer tissues compared to paired non-cancerous colon tissues. There was a positive correlation between MTDH and SND1 expression in colon cancer tissues (r = 0.86, p < 0.001). In addition, their positive expression were both significantly associated with nodal status (both p = 0.02), pathological stage (p = 0.006 and 0.008, respectively) and differentiation (both p = 0.03). Moreover, the overall survival in colon cancer patients with positive expression of MTDH and SND1 were significantly shorter than those without their expression (both p = 0.01). Furthermore, multivariate Cox regression analysis suggested that positive expression of MTDH and SND1 was an independent poor prognostic predictor in colon cancer. Our data suggest that the increased expression of MTDH and/or SND1 is closely related to carcinogenesis, progression, and prognosis of colon cancer. The co-expression of MTDH/SND1 may be a novel distinctive marker to benefit us in prediction of the prognosis in colon cancer.