Vitamin D receptor gene polymorphisms, bone mineral density and fractures in postmenopausal women with osteoporosis

• DOI: 10.1007/s11033-012-2072-3
• Publication Date: 2012-10-17T12:43:41Z
• Authors: Wanda Horst-Sikorska; Joanna Dytfeld; Anna Wawrzyniak; Michalina Marcink...; Michał Michalak; Edward Franek; Luiza Napiórkowska; Natalia Drwęska; Ryszard Słomski
• Keywords: TaqI

The goal of the study was to investigate possibility an association between polymorphisms and single alleles BsmI, ApaI, TaqI vitamin D receptor (VDR) gene with bone mineral density (BMD) prevalence vertebral/non-vertebral fractures in a group postmenopausal Polish women osteoporosis. comprised 501 females osteoporosis (mean age 66.4 ± 8.9), who were diagnosed on basis either WHO criteria or self-reported history low-energy fractures. three determined by PCR (polymerase chain reaction) RFLP (restriction fragment length polymorphism). BMD at lumbar spine femoral neck assessed dual energy X-ray absorptiometry (DXA). 285 reported whole (168 vertebral 117 non-vertebral). Incidence non-vertebral significantly higher carriers b BsmI T VDR (p = 0.021, 0.032, 0.020, respectively). No significant associations allelic variants studied fracture incidence found. (1).The presence a,b respectively, might serve as indicator (2). Lack suggests that contributes also through other ways.