Vitamin D receptor gene BsmI, FokI, ApaI and TaqI polymorphisms and the risk of systemic lupus erythematosus

• DOI: 10.1007/s11033-012-2118-6
• Publication Date: 2012-10-17T17:05:36Z
• Authors: Adrianna Mostowska; Margarita Lianeri; Mariusz Wudarski; Marzena Olesińska; Paweł P. Jagodziński
• Keywords: FokI; TaqI

Recently, several studies have demonstrated the role of vitamin D receptor (VDR) polymorphisms in development systemic lupus erythematosus (SLE); however, these results are inconsistent between different cohorts. Therefore, we studied prevalence VDR FokI (rs2228570), BsmI (rs1544410), ApaI (rs7975232) and TaqI (rs731236) genotypes alleles SLE patients (n = 258) healthy individuals 545) a Polish population. We did not observe significant differences for either FokI, BsmI, genotype allele frequencies with individuals. However, frequency F/F F/f was statistically renal disease without this symptom OR 3.228 (1.534-6.792, p 0.0014), (corr) 0.0476)]. There no association clinical manifestations laboratory profiles SLE. Our study indicates that variant might increase risk some presentations