SETDB1 deletion causes DNA demethylation and upregulation of multiple zinc-finger genes

• DOI: 10.1007/s11033-024-09703-2
• Publication Date: 2024-06-21T13:01:55Z
• Authors: Yong-Kook Kang; Jaemin Eom; Byungkuk Min; Jung Sun Park
• Keywords: Heterochromatin protein 1

SETDB1 (SET domain bifurcated-1) is a histone H3-lysine 9 (H3K9)-specific methyltransferase that mediates heterochromatin formation and repression of target genes. Despite the assumed functional link between DNA methylation SETDB1-mediated H3K9 trimethylations, several studies have shown operates autonomously in region- cell-specific manner. This study analyzes SETDB1-null HAP1 cells through linked methylome transcriptome analysis, intending to explore genes controlled by SETDB1-involved methylation.