Cutaneous Cryptococccosis Due to Cryptococcus gattii in Immunocompetent Hosts: Case Report and Review

• DOI: 10.1007/s11046-006-0277-5
• Publication Date: 2006-03-21T15:49:52Z
• Authors: José Miguel Dora; Silvia Kelbert; Caroline Deutsche...; Vanessa S. Cunha; Valério R. Aquino; Rodrigo Pires dos...; Luciano Zubaran G...
• Keywords: Male; Cryptococcus; 0303 health sciences; 03 medical and health sciences; Antifungal Agents; Dermatomycoses; Humans; Cryptococcosis; Middle Aged; Immunocompetence; 3. Good health

Cutaneous cryptococcosis caused by C. gattii, in immunocompent patients is a rare manifestation of disease, and may be one of the first manifestations of disseminated cryptococcosis. We report a case of disseminated cryptococcosis caused by Cryptococcus gattii presenting as cutaneous lesions in an immunocompetent patient. Previously to our report, only five cases of cutaneous involvement by Cryptococcus gattii in immunocompetent patients have been reported in the literature. Risk factors for C. gattii infection included exposure to the eucalypt reservoirs in tropical and subtropical areas. Skin involvement corresponded to the disseminated form of cryptococcosis in the majority of patients, and commonly affected the face and neck with different morphologies including papules, pustules, plaques, ulcers, subcutaneous masses, cellulitis or acneiform lesions. Due to the severity of this infection and the life threatening condition that it represents, clinicians must be aware that cutaneous involvement may be one of the first manifestations of disseminated cryptococcosis caused by C. gattii especially in patients living and coming from endemic areas.