Idebenone Antagonizes P53-Mediated Neuronal Oxidative Stress Injury by Regulating CD38-SIRT3 Protein Level

• DOI: 10.1007/s11064-024-04189-7
• Publication Date: 2024-06-12T03:36:30Z
• Authors: Hao Xu; Ying Guo; Xiao-Jun Liu; Ying Liu; Shi Yin; Qi-Ying Bao; Ru Peng; Wei-Bo Tian; Ying-Yan Xia; Ling Gao; Jia-Mei Liu
• Keywords: Idebenone; SIRT3; Coenzyme Q10

Idebenone, an antioxidant used in treating oxidative damage-related diseases, has unclear neuroprotective mechanisms. Oxidative stress affects cell and mitochondrial membranes, altering Adp-ribosyl cyclase (CD38) Silent message regulator 3 (SIRT3) protein expression possibly impacting SIRT3's ability to deacetylate Tumor p53 (P53). This study explores the relationship between CD38, SIRT3, P53 H