Synthesis and pharmacological activity of 9-R-2-halogenophenylimidazo[1,2-a]benzimidazoles

• DOI: 10.1007/s11094-010-0465-y
• Publication Date: 2010-11-11T21:12:17Z
• Authors: V. A. Anisimova; A. A. Spasov; I. E. Tolpygin; V. I. Minkin; M. V. Chernikov; D. S. Yakovlev; A. Yu. Stukovina; I. I. Goryagin; O. Yu. Grechko; N. V. Kirillova; V. A. Kosolapov; E. V. Tibir’kova; O. A. Salaznikova; L. V. Naumenko; N. A. Gurova
• Keywords: 0301 basic medicine; 03 medical and health sciences; 3. Good health

Taking into account the structure—activity relationship established previously for imidazobenzimidazole derivatives with high hemorheological activity, several new 9-R-2-halogenophenyl-substituted imidazo[1,2-a]benzimidazoles with C2 fluoro-, chloro-, dichloro-, or bromo-phenyl radicals have been synthesized. All substances were tested in vitro for various types of pharmacological activity characteristic of this class of drugs including hemorheological, antiplatelet, antiarrhythmic, antioxidant; 5-HT2-, 5-HT3-, P2Y1-, and H1-antagonist; and κ-opioid-agonist.