Synthesis and pharmacological activity of amides of 2,3-dihydroimidazo- and 2,3,4,10-tetrahydropyrimido[1,2-a]benzimidazolyln-acetic acids

• DOI: 10.1007/s11094-013-0862-0
• Publication Date: 2013-03-09T02:59:14Z
• Authors: V. A. Anisimova; A. A. Spasov; V. A. Kosolapov; I. E. Tolpygin; E. V. Tibir’kova; O. A. Salaznikova; V. A. Kuznetsova; N. A. Gurova; K. V. Lenskaya; D. S. Yakovlev; D. V. Mal’tsev; N. A. Kolobrodova; T. M. Mitina; O. Yu. Grechko
• Keywords: 0303 health sciences; 03 medical and health sciences; 3. Good health

A series of amides of 2,3-dihydroimidazo- and 2,3,4,10-tetrahydropyrimido[1,2-a]benzimidazolyl-N-acetic acids were synthesized. Their pharmacological activity was studied. It was established that the synthesized substances possessed antiaggregant properties and antiarrhythmic activity. Some of these amides exhibited antioxidant and hypoglycemic effects in addition to antagonist activity with respect to serotonin 5-HT2 and purine P2Y1 receptors.