Development and Validation of a Method for Determining Lidocaine Hydrochloride and Miramistin in an Innovative Wound-Healing Gel

• DOI: 10.1007/s11094-020-02158-2
• Publication Date: 2020-04-19T05:02:23Z
• Authors: L. L. Brkich; P. A. Markin; N. E. Moskaleva; N. V. Pyatigorskaya; G. E. Brkich; A. V. Panov; M. A. Grin
• Keywords: Lidocaine Hydrochloride; Linear relationship; Linear correlation

An HPLC-UV method for quantitative determination of lidocaine and miramistin in a combination wound-healing gel is reported. The method was validated for specificity, linearity, accuracy, and precision. The linear range for lidocaine hydrochloride was 0.08 – 0.12 mg/mL; for miramistin, 0.04 – 0.06 mg/mL. The linear correlation coefficients were 0.9992 and 0.9996 for lidocaine hydrochloride and miramistin, respectively. The method could be used for quantitative evaluation of lidocaine and miramistin in combination medicines.