Essential Oil Contents of Hypericum linarioides, H. helianthemoides, and H. lydium with Their Biological Activities: Importance of Hypericum Genus in the Cosmeceutical and Pharmaceutical Industries

• DOI: 10.1007/s11094-023-03011-y
• Publication Date: 2024-01-03T19:03:02Z
• Authors: Mehmet Akdeniz; Ismail Yener; Abdulselam Ertas; Demet Dincel; Mehmet Firat; Safak Ozhan Kocakaya; Serkan Yiğitkan; Fatma Pınar Türkm...; Firat Aydin; Ufuk Kolak
• Keywords: 0303 health sciences; 03 medical and health sciences

In the literature, more than 3000 studies have been carried out on species in the Hypericum genus in the lastten years, especially for H. perforatum. The importance of Hypericum species in traditional medicine andmodern medicine is increasing day by day. From this point of view, the chemical composition of H. linarioides,H. helianthemoides, and H. lydium essential oils was analyzed by GC-MS/FID. In addition, their antioxidant,cytotoxic and antimicrobial activities along with their enzyme inhibitory potentials (cholinesterase,urease, tyrosinase, elastase and, collagenase) were defined. Also, in vitro and in silico studies of the majorcomponents of the species have been carried out on the studied enzymes. H. linarioides and H. helianthemoideswere found to be rich in monoterpene hydrocarbons (63.96% and 43.86%, respectively), and H. lydiumin sesquiterpene hydrocarbons (48.41%). The major components were indicated as -pinene for H. linarioides(50.39%) and for H. helianthemoides (36.84%), and -selinene for H. lydium (10.12%). H. lydium essentialoil exhibited very high cytotoxic activity on breast cancer (MCF-7) (selectivity indices SI: 12) and coloncancer (HT-29) (SI: 2) cell lines. In particular, the selectivity indice value in MCF-7 cell lines of H. lydiumcould have natural therapeutic potential for breast cancer. H. lydium possessed neuropharmacological potentialdue to its high anticholinesterase activity. Since H. linarioides indicated high anti-aging potential(tyrosinase, elastase, and collagenase enzyme inhibitory activities), it could be used in the cosmetic industry.