Condition-specific or generic preference-based measures in oncology? A comparison of the EORTC-8D and the EQ-5D-3L

• DOI: 10.1007/s11136-016-1443-y
• Publication Date: 2016-11-09T14:21:35Z
• Authors: Paula K. Lorgelly; Brett Doble; Donna Rowen; John Brazier
• Keywords: EQ-5D; Baseline (sea)

It has been argued that generic health-related quality of life measures are not sensitive to certain disease-specific improvements; condition-specific preference-based may offer a better alternative. This paper assesses the validity, responsiveness and sensitivity cancer-specific measure, EORTC-8D, relative EQ-5D-3L. A longitudinal prospective population-based cancer genomic cohort, Cancer 2015, was utilised in analysis. EQ-5D-3L EORTC QLQ-C30 (which gives EORTC-8D values) were asked at baseline (diagnosis) various follow-up points (3 months, 6 12 months). Baseline values assessed for convergent ceiling effects, agreement sensitivity. Quality-adjusted life-years (QALYs) estimated similarly assessed. Multivariate regression analyses employed understand determinants difference QALYs. Complete case analysis 1678 patients found significantly lower than (0.748 vs 0.829, p < 0.001). While correlation between instruments high, poor. The health state using both be number patient disease characteristics, discrimination states similar. Mean QALYs (estimated EQ-5D-3L) EORTC-8D) (0.860 0.909, discriminatory power When comparing instrument, divergences apparent over time patients. variability QALY estimations means researchers decision makers advised cautious if interchangeably.