Synthesis of 5,4″-di-O-succinoylavermectin B1

• DOI: 10.1007/s11172-016-1684-5
• Publication Date: 2017-05-25T06:40:01Z
• Authors: E. I. Chernoburova; K. V. Danchenko; M. A. Shchetinina; A. A. Zharov; A. V. Kolobov; M. Kh. Dzhafarov; F. I. Vasilevich; I. V. Zavarzin
• Keywords: 01 natural sciences; 3. Good health; 0104 chemical sciences

A reaction of avermectin B1 with succinic anhydride at ultrahigh pressure (10 kbar) gave previously unavailable 5,4″-di-O-succinoylavermectin B1, which is of interest as potential antiparasitic agent.