Calcium Chloride (CaCl2) as Catalyst for Asymmetric Organic Reactions

• DOI: 10.1007/s11244-014-0254-z
• Publication Date: 2014-03-27T16:11:32Z
• Authors: Tetsu Tsubogo; Yasuhiro Yamashita; Shū Kobayashi
• Keywords: Organic Synthesis

Pybox–CaCl2 was found to be an efficient chiral catalyst for asymmetric 1,4-addition reactions of 1,3-dicarbonyl compounds with nitroalkenes, affording γ-nitro carbonyl compounds in high yields with high enantioselectivities. The reactions proceeded smoothly even in air, and were successfully applied to a continuous flow system.