Interleukin 6 is a better predictor of 5-year cardiovascular mortality than high-sensitivity C-reactive protein in hemodialysis patients using reused low-flux dialyzers

• DOI: 10.1007/s11255-020-02461-7
• Publication Date: 2020-04-18T05:02:47Z
• Authors: Le Viet Thang; Nguyen Duc Loc; Nguyen Trung Kien; Nguyen Huu Dung; Dao Bui Quy Quyen; Nguyen Minh Tuan; Do Manh Ha; Truong Quy Kien; Nguyen Thi Thuy Dung; Diem Thi Van; Nguyen Van Duc; Nguyen Thi Thu Ha; Pham Quoc Toan; Vu Xuan Nghia
• Keywords: Adult; Male; Time Factors; Interleukin-6; Middle Aged; 3. Good health; 03 medical and health sciences; C-Reactive Protein; 0302 clinical medicine; Cardiovascular Diseases; Predictive Value of Tests; Renal Dialysis; Equipment Reuse; Humans; Female

In this study, we focused on the role of elevated serum interleukin 6 (IL-6) concentration in predicting 5-year cardiovascular mortality in hemodialysis patients using low-flux dialyzer reuse.We measured serum IL-6 concentrations in 236 hemodialysis patients (138 males and 98 females) to predict 5-year cardiovascular mortality. We assessed the baseline demographics of all patients who had a mean age of 44 years and a median hemodialysis duration of 38.5 months. We divided all patients into two equal groups based on the serum IL-6 concentration: G1 (n = 118) with serum IL-6 concentration < 6.78 pg/L and G2 (n = 118) with serum IL-6 concentration ≥ 6.78 pg/L.After the 5-year follow-up, 45 patients died due to cardiovascular causes (19.1%). Lipid disorder, hemoglobin, serum albumin, β2-M, and IL-6 concentration were independent risk factors for predicting cardiovascular mortality during the 60-month follow-up in hemodialysis patients. Based on the Kaplan-Meier analysis, we realized that patients with a higher interleukin 6 concentration (G2) had a significantly higher cardiovascular mortality rate than patients in G1 (log-rank test p < 0.001). Serum IL-6 concentration was a better predictor of 5-year cardiovascular mortality than high-sensitivity C-reactive protein in hemodialysis patients using low-flux dialyzer reuse (AUC = 0.818; p < 0.001; cut-off value: 8.055 pg/mL, Se = 77.8%, Sp = 78.5%).Serum IL-6 concentration was a better predictor of 5-year cardiovascular mortality than high-sensitivity C-reactive protein in maintenance hemodialysis patients using low-flux dialysis reuse.