Unveiling the metabolomic profile of growth hormone deficiency children using NMR spectroscopy

• DOI: 10.1007/s11306-024-02217-9
• Publication Date: 2025-02-07T19:13:06Z
• Authors: Eftychia A. Aggelaki; Aristeidis Gianna...; Panagiota D. Geor...; Styliani A. Chasapi; Alexandra Efthymi...; Dimitra Kritikou; Dionisios Chrysis; Georgios A. Spyro...
• Keywords: Metabolome; Mendelian Randomization

Abstract Introduction The diagnosis of Growth Hormone Deficiency (GHD) during childhood has been the subject much controversy over last few years. Aiming to accurate medical treatment, there is a need for biomarker discovery. Objective To characterize metabolic profile GHD children, examine effect GH administration on signature, and investigate correlations between metabolites IGF-1. Methods Nuclear Magnetic Resonance (NMR)-based untargeted targeted metabolomic approach applied study profiles children with GHD. Plasma, serum, urine samples were collected from twenty-two diagnosed forty-eight age matched controls Pediatric Endocrinology Unit University Hospital Patras. Experimental data examined by both multivariate univariate statistical analysis. Results results this pilot revealed different fingerprint in comparison age-matched healthy individuals. However, detected alterations metabolite patterns before after treatment subtle minor discriminative power. Conclusions This provides evidence that metabolome plays pivotal role GHD, but large-scale multicenter studies are warranted validate results.