PET Imaging of a Transgenic Tau Rat Model SHR24 with [18F]AV1451

• DOI: 10.1007/s11307-024-01972-4
• Publication Date: 2025-01-21T20:28:59Z
• Authors: Nisha K. Ramakris...; Annie Ziyi Zhao; Stephen Thompson; Selena Milicevic ...; David J. Williamson; Tomáš Smolek; Norbert Žilka; Franklin I. Aigbi...
• Keywords: Binding potential; Partial volume; Tau Pathology

Abstract Purpose Positron Emission Tomography (PET) scans with radioligands targeting tau neurofibrillary tangles (NFT) have accelerated our understanding of the role misfolded in neurodegeneration. While intended for human research, applying these to small animals establishes a vital translational link. Transgenic animal models dementia, such as rat SHR24, play crucial enhancing disorders. This study aims evaluate utility SHR24 model PET studies. Procedures Dynamic were conducted male rats and their wild-type SHR (SHRwt) littermates using [ 18 F]AV1451. Rapid blood sampling metabolite analysis performed acquire input curves. Time activity curves obtained from various brain regions over 60 min. Blood-based, 2-Tissue Compartment Model (2-TCM) Logan graphical used obtain kinetic modelling parameters. The ability reference tissue predict binding potential (BP ND ) assessed. Autoradiography studies corroborate scan data. Results Total distribution volume (V T was best predicted parameter which revealed significantly higher uptake F]AV1451 cortex (5.8 ± 1.1 vs 4.6 0.7, P < 0.05) compared SHRwt rats. Binding 2-TCM variable, however BP detected (0.28 0.07 0.20 0.04, 0.01 by SRTM) brainstem (0.14 0.04 0.08 0.02, 0.01, SRTM). Conclusions With detect established radioligand rats, we demonstrated this assessing aggregated neurobiology PET, providing longitudinal