Gender-specific effects of prenatal mixed exposure to serum phthalates on neurodevelopment of children aged 2–3 years:the Guangxi Birth Cohort Study

• DOI: 10.1007/s11356-022-21769-8
• Publication Date: 2022-07-07T01:02:46Z
• Authors: Yuan Zheng; Longman Li; Hong Cheng; Shengzhu Huang; Xiuming Feng; Lulu Huang; Luyun Wei; Dehao Cao; Sida Wang; Long Tian; Weijun Tang; Caitong He; Chunhua Shen; Bangzhu Luo; Maoling Zhu; Tao Liang; Baohong Pang; Mujun Li; Chaoqun Liu; Xing Chen; Fei Wang; Zengnan Mo; Xiaobo Yang
• Keywords: Male; 0301 basic medicine; China; Phthalic Acids; Environmental Exposure; 3. Good health; Cohort Studies; 03 medical and health sciences; Pregnancy; Humans; Female; Birth Cohort; Environmental Pollutants; Child

Phthalates have been shown to have adverse effects on neurodevelopment, which may be gender-specific. However, the association between prenatal mixed exposure to phthalates and children's neurodevelopment remains inconsistent. We measured 15 prenatal serum phthalate levels and evaluated children's neurodevelopmental indicators using Gesell Developmental Schedule (GDS) (n = 750). Generalized linear regression was fitted to examine the association. Among boys, mono-2-ethyl-5-hydroxyhexyl phthalate (MEHHP) had adverse effects on gross motor [odds ratio (OR): 7.38, 95% confidence interval (CI):1.42, 38.46]. For gross motor in boys, joint effect was discovered between mono-2-ethylhexyl phthalate (MEHP) and MEHHP. Moreover, synergistic effects were found for MEHP with vanadium and cadmium, and antagonistic effects for MEHP with magnesium, calcium, titanium, iron, copper, selenium, rubidium, and strontium. We did not find statistically significant relationships in girls. In the 1st trimester, adverse effects were identified between mono-2-ethyl-5-oxoyhexyl phthalate (MEOHP) and adaptation (P = 0.024), and monomethyl phthalate (MMP) with social area (P = 0.017). In the 2nd trimester, MEHHP had adverse effects on social area (P = 0.035). In summary, we found boys may be more vulnerable to the neurotoxicity than girls in gross motor, and we also discovered the detrimental effects of phthalates on children's neurodevelopment in the 1st and 2nd trimesters. Therefore, the supplementation of appropriate elements in the 1st and 2nd trimesters may help reduce the adverse effects of phthalates on children's neurodevelopment, especially among boys.