Personal exposure of PM2.5 and metabolic syndrome markers of pregnant women in South Korea: APPO study

• DOI: 10.1007/s11356-023-30921-x
• Publication Date: 2023-11-23T17:02:18Z
• Authors: Yeonseong Jeong; Sunwha Park; Eunjin Kwon; Young Min Hur; Young-Ah You; Soo Min Kim; Gain Lee; Kyung A. Lee; Soo Jung Kim; Geum Joon Cho; Min-Jeong Oh; Sung Hun Na; Se jin Lee; Jin-Gon Bae; Yu-Hwan Kim; Soo-Jeong Lee; Young-Han Kim; Young Ju Kim
• Keywords: 0301 basic medicine; 03 medical and health sciences; Lipid metabolism; Pregnancy complications; Metabolic dysfunction; Indoor air pollution; Glucose intolerance; Particulate matter; Research Article

We examined the association between exposure to PM2.5, focused on individual level, and metabolic dysfunction during pregnancy. APPO study (Air Pollution Pregnancy Outcome) was a prospective, multicenter, observational cohort conducted from January 2021 March 2023. Individual PM2.5 concentrations were calculated using time-weighted average model. Metabolic pregnancy assessed based modified definition of syndrome its components, accounting for pregnancy-specific criteria. Exposure associated with worsened parameters especially glucose metabolism. In comparison participants exposed low group, those high levels exhibited increased odds gestational diabetes mellitus (GDM) after adjusting confounding variables in different adjusted models. Specifically, model 1, ratio (aOR) 3.117 95% confidence interval (CI) 1.234-7.870; 2, aOR 3.855 CI 1.255-11.844; 3, 3.404 1.206-9.607; 4, 2.741 0.712-10.547. higher tendency worsen markers specifically homeostasis. Further research is needed investigate mechanisms underlying effects ambient