Age-associated impaired plasmacytoid dendritic cell functions lead to decreased CD4 and CD8 T cell immunity

• DOI: 10.1007/s11357-010-9191-3
• Publication Date: 2010-10-15T05:41:18Z
• Authors: Aishwarya Sridharan; Marc Esposo; Khushboo Kaushal; Jia Tay; Kathyrn Osann; Sudhanshu Agrawal; Sudhir Gupta; Anshu Agrawal
• Keywords: Plasmacytoid dendritic cell; Granzyme

Increased susceptibility to infections, particularly respiratory viral is a hallmark of advancing age. The underlying mechanisms are not well understood, and there scarcity information regarding the contribution innate immune system, which first line defense against infections. In present study, we have investigated effect age on plasmacytoid dendritic cell (PDC) function because they critical in generating robust antiviral response via secretion interferons (IFN). Our results indicate that PDCs from aged impaired their capacity secrete IFN-I influenza virus CPG stimulation. Additionally, observed severe reduction production IFN-III, plays an important role infections at mucosal surfaces. This IFN-III were result age-associated phosphorylation transcription factor, IRF-7. Furthermore, be induce perforin granzyme CD8 T cells. Comparison antigen-presenting PDC with young revealed subjects display reduced proliferation IFN-gamma CD4 cells as compared subjects. summary, our study demonstrates has profound multiple levels may therefore, responsible for increased elderly.