The relationship between 11 different polygenic longevity scores, parental lifespan, and disease diagnosis in the UK Biobank

• DOI: 10.1007/s11357-024-01107-1
• Publication Date: 2024-03-07T11:42:01Z
• Authors: Janith Don; Andrew J. Schork; Gwênlyn Glusman; Noa Rappaport; Steve R. Cummings; David Duggan; Anish Raju; Kajsa-Lotta Georg...; Sophia Gunn; Stefano Monti; Thomas Perls; Jodi Lapidus; Laura H. Goetz; Paola Sebastiani; Nicholas J. Schork
• Keywords: Genome-wide Association Study; Genetic architecture; Genetic Association

Abstract Large-scale genome-wide association studies (GWAS) strongly suggest that most traits and diseases have a polygenic component. This observation has motivated the development of disease-specific “polygenic scores (PGS)” are weighted sums effects disease-associated variants identified from GWAS correlate with an individual’s likelihood expressing specific phenotype. Although been pursued on disease traits, leading to creation refined “Polygenic Risk Scores” (PRS) quantify risk diseases, many also extreme human longevity, general fitness, health span, other health-positive traits. These discovered genetic seemingly protective often different (i.e., they not just alternative alleles at loci) basis. led interest in longevity (PLS)” “risk” or predisposition individual towards health. We derived 11 PLS 4 available lifespan then investigated properties these using data UK Biobank (UKB). Tests between population structure, parental lifespan, several cancerous non-cancerous including death COVID-19, were performed. Based results our analyses, we argue made up only robustly associated but contribute architecture susceptibility, morbidity, mortality.