Associations between epigenetic aging and diabetes mellitus in a Swedish longitudinal study

• DOI: 10.1007/s11357-024-01252-7
• Publication Date: 2024-06-27T16:19:44Z
• Authors: Daniel Wikström S...; Shayan Mostafaei; Bowen Tang; Nancy L Pedersen; Ida K Karlsson; Tove Fall; Sara Hägg
• Keywords: dNaM; Longitudinal Study

Diabetes mellitus type 2 (T2D) is associated with accelerated biological aging and the increased risk of onset other age-related diseases. Epigenetic changes in DNA methylation levels have been found to serve as reliable biomarkers for aging. This study explores relationship between various epigenetic diabetes using longitudinal data. Data from Swedish Adoption/Twin Study Aging (SATSA) was collected 1984 2014 included 536 individuals at least one measurement. The following were employed: DNAm PAI-1, DNAmTL, DunedinPACE, PCHorvath1, PCHorvath2, PCHannum, PCPhenoAge, PCGrimAge. Firstly, analysis biomarker trajectories done. Secondly, linear correlations time studied within developing diabetes. Thirdly, Cox proportional hazards (PH) models used assess associations these diagnosis, adjustments chronological age, sex, education, smoking, blood glucose, BMI. revealed differences without Smoothened average curves DunedinPACE PAI-1 higher around age 60-70, compared controls. Likewise, closer onset. However, no significant PH models. Our findings suggest potential value specifically tailored T2D, should we wish model explore predicting disease.