Longitudinal gut fungal alterations and potential fungal biomarkers for the progression of primary liver disease

• DOI: 10.1007/s11427-023-2458-1
• Publication Date: 2024-02-28T01:02:03Z
• Authors: Shiman Jiang; Lvwan Xu; Yanfei Chen; Zheyue Shu; Longxian Lv; Yuxi Zhao; Kefan Bi; Sisi Yang; Qiangqiang Wang; Lanjuan Li
• Keywords: Chytridiomycota

Abstract Liver disease, a major health concern worldwide, is serious and progressive disorder. Herein, we not only established mouse model of DEN+CCl 4 -induced primary liver disease but also collected clinical human samples to investigate longitudinal alterations in the gut mycobiome. As advanced, integrity was disrupted, mycobiota disturbed models. The metabolites associated with hepatocellular carcinoma (HCC) differed from those cirrhotic phase as follows: levels stercobilin aflatoxin B1 dialcohol were reduced, while triterpenoids, bafilomycin A1, DHEA increased HCC group. abundance phylum Chytridiomycota chronic progressed then replaced by Ascomycota HCC. Based on results samples, genus Candida (Ascomycota) (in humans) Kazachstania mice) occupied dominant position group, other fungi depleted. C. albicans depletion S. cerevisiae may be hallmarks progression cirrhosis early Moreover, administration LC-HCC could accelerate or retard Therefore, have potential serve noninvasive biomarker even treatment method.