Finding neoepitopes in mouse models of personalized cancer immunotherapy

• DOI: 10.1007/s11515-016-1422-2
• Publication Date: 2016-11-08T05:33:02Z
• Authors: Sahar Al Seesi; Alok Das Mohapatra; Arpita Pawashe; Ion I. Mandoiu; Fei Duan
• Keywords: Cancer Immunotherapy

Background Cancer immunotherapy uses one’s own immune system to fight cancerous cells. As immune system is hard-wired to distinguish self and non-self, cancer immunotherapy is predicted to target cancerous cells specifically, therefore is less toxic than chemotherapy and radiation therapy, two major treatments for cancer. Cancer immunologists have spent decades to search for the specific targets in cancerous cells.