Application of gene expression programming and neural networks to predict adverse events of radical hysterectomy in cervical cancer patients

• DOI: 10.1007/s11517-013-1108-8
• Publication Date: 2013-10-17T17:21:30Z
• Authors: Maciej Kusy; Bogdan Obrzut; Jacek Kluska
• Keywords: Adult; Biomedical Engineering; Uterine Cervical Neoplasms; Hysterectomy; 03 medical and health sciences; Postoperative Complications; 0302 clinical medicine; Predictive Value of Tests; Humans; Computer Simulation; Prospective Studies; Aged; Models, Statistical; Gene Expression Profiling; Computational Biology; Middle Aged; Computer Science Applications; 3. Good health; Treatment Outcome; ROC Curve; Original Article; Female; Neural Networks, Computer; Algorithms

The aim of this article was to compare gene expression programming (GEP) method with three types of neural networks in the prediction of adverse events of radical hysterectomy in cervical cancer patients. One-hundred and seven patients treated by radical hysterectomy were analyzed. Each record representing a single patient consisted of 10 parameters. The occurrence and lack of perioperative complications imposed a two-class classification problem. In the simulations, GEP algorithm was compared to a multilayer perceptron (MLP), a radial basis function network neural, and a probabilistic neural network. The generalization ability of the models was assessed on the basis of their accuracy, the sensitivity, the specificity, and the area under the receiver operating characteristic curve (AUROC). The GEP classifier provided best results in the prediction of the adverse events with the accuracy of 71.96 %. Comparable but slightly worse outcomes were obtained using MLP, i.e., 71.87 %. For each of measured indices: accuracy, sensitivity, specificity, and the AUROC, the standard deviation was the smallest for the models generated by GEP classifier.