Modeling Optimal Intervention Strategies for Cholera

• DOI: 10.1007/s11538-010-9521-8
• Publication Date: 2010-03-03T16:55:05Z
• Authors: Rachael L. Miller...; Elsa Schaefer; Holly Gaff; K. Renee Fister; Suzanne Lenhart
• Keywords: Cholera; Basic reproduction number

While cholera has been a recognized disease for two centuries, there is no strategy for its effective control. We formulate a mathematical model to include essential components such as a hyperinfectious, short-lived bacterial state, a separate class for mild human infections, and waning disease immunity. A new result quantifies contributions to the basic reproductive number from multiple infectious classes. Using optimal control theory, parameter sensitivity analysis, and numerical simulations, a cost-effective balance of multiple intervention methods is compared for two endemic populations. Results provide a framework for designing cost-effective strategies for diseases with multiple intervention methods.