Epidural and Non-epidural Analgesia in Patients Undergoing Open Pancreatectomy: a Retrospective Cohort Study

• DOI: 10.1007/s11605-019-04136-w
• Publication Date: 2019-02-27T02:39:08Z
• Authors: Jesse V. Groen; David E.F. Slotboom; Jaap Vuyk; Chris H. Martini; Albert Dahan; Alexander L. Vahr...; Bert A. Bonsing; J. Sven D. Mieog
• Keywords: Adult; Male; Pain, Postoperative; Morphine; Epidural analgesia; Pain; Middle Aged; 3. Good health; Analgesia, Epidural; Analgesics, Opioid; Cohort Studies; 03 medical and health sciences; Pancreatectomy; Treatment Outcome; 0302 clinical medicine; Fluid therapy; Humans; Original Article; Administration, Intravenous; Female; Aged; Pain Measurement; Retrospective Studies

The use of epidural analgesia (EA) in pancreatic surgery remains under debate. This study compares patients treated with EA versus non-EA after open pancreatectomy a tertiary referral center. All undergoing from 2013 to 2017 were retrospectively reviewed. (Non-)EA was terminated on postoperative day (POD) 3 or earlier if required. In total, 190 (72.5%) received and 72 (27.5%) (mostly intravenous morphine). prematurely 32.6% 10.5% patients. Compared patients, had significantly lower pain scores POD 0 (1.10 (0–3.00) 3.00 (1.67–5.00), P < 0.001) 1 (2.00 (0.50–3.41) (2.00–3.80), = 0.001), though higher (3.00 (2.00–4.00) 2.33 (1.50–4.00), 4 (2.50 (1.50–3.67) 2.00 (0.50–3.00), 0.007). required more vasoactive medication perioperatively cumulative fluid balances 1–3. Postoperative complications similar between groups. our cohort, experienced the first PODs compared non-EA, yet been terminated. Although therapy, complication rate similar.