Detection of tumor mutant DNA in plasma of patient with colorectal cancer

• DOI: 10.1007/s11670-002-0034-3
• Publication Date: 2007-07-28T21:33:21Z
• Authors: Ming Li; Wen-hui Wan; Jin Gu
• Keywords: Microsatellite Instability; Circulating tumor DNA; Tumor M2-PK

Early diagnosis and prompt treatment are mandatory to prevent colorectal cancer. Detection of free circulating tumor DNA in the serum cancer patients provides new possibilities for diagnosis. Several DNAs have been identified by PCR detection such as activated K-ras oncogene, inactivated APC, p53 genes, microsatellite instability (MSI). Circulating was predominantly found with advanced disease poor prognosis. It suggested that analysis might be useful early