Increased apoptosis in lymphoma bone marrow erythroid cells: Possible anemic pathophysiologic significance

• DOI: 10.1007/s11670-004-0021-y
• Publication Date: 2007-08-03T07:37:09Z
• Authors: Jun-xia Gu; Yan Chen; Chun Zhang; Hong-li Liu; Zhong-ping Liu; jin-e Zheng; Jun-xia Yao
• Keywords: 03 medical and health sciences; 0302 clinical medicine

Objective: To investigate whether excessive erythroid cell apoptosis and/or suppression of proliferation would be implicated in the pathogenesis of anemia associated with lymphoma. Methods: Bone marrow (BM) erythroid cell (CD71+, GPA+ apoptosis (annexin V) and proliferation (Ki-67) were measured by flow cytometry in lymphoma patients and normal donors. Results: BM CD71+ and GPA+ cells showed a significantly greater proportion of apoptotic cells in lymphoma than in normal samples. Proliferation rate was also significantly increased in lymphoma BM CD71+ and GPA+ cells than in normal samples. Conclusion: Increased apoptosis in lymphoma BM erythroid cells may contribute to the anemia characteristic of this disorder. Proliferation might be up-regulated on BM erythroid cells via negative feedback loop resulting from a state of apoptosis.