Detection of human papillomavirus L1 -16 and -18 DNA and epstein-barr virus DNA in laryngeal carcinoma

• DOI: 10.1007/s11670-005-0056-8
• Publication Date: 2007-07-28T21:49:22Z
• Authors: Bao-guo Liu; Zhe-ming Lu; Yong Li; Hai-rong Jiang; Fei Liao; Fang-yi Peng; Xiao-song Rao; Rong-rui Chen; Nai-song Zhang; Jian-jun Wang; Yang Ke
• Keywords: Pathogenesis

Objective: To look for the further evidence HPV L1 HPV16 E6, 18 E6 and EBV as carcinogenic factors in laryngeal carcinoma. Method: we examined representative numbers of specimens from cancer with highly sensitive PCR technique presence high-risk types HPV18 LMP1. Results: Using detection, 7.3% samples were positive, 52.03% 30.89% positive 9.13% LMP1 positive. The low incidence high HPV-16 genes suggest that might be integrated into tumor cells. Our results support a role HPV-18 infection pathogenesis carcinoma China. Conclusion: Integration host genome stable expression these may associated carcinogenesis synergistically function on an association 16, EBV.