Long-term Metabolic Effects of Laparoscopic Sleeve Gastrectomy

• DOI: 10.1007/s11695-018-3153-8
• Publication Date: 2018-03-01T13:23:42Z
• Authors: Danila Capoccia; Federica Coccia; Gloria Guarisco; Moira Testa; Roberta Rendina; Francesca Abbatini; Gianfranco Silecchia; Frida Leonetti
• Keywords: Adult; Blood Glucose; Male; 2. Zero hunger; Remission Induction; bariatric surgery; obesity; type 2 diabetes; Middle Aged; Obesity, Morbid; 3. Good health; 03 medical and health sciences; Treatment Outcome; 0302 clinical medicine; Diabetes Mellitus, Type 2; Gastrectomy; Recurrence; Hypertension; Weight Loss; Humans; Insulin; Female; Laparoscopy; Dyslipidemias

Obesity is one of the major health challenges throughout the world. The association between obesity and diabetes is well established because 90% of patients with type 2 diabetes mellitus (T2DM) show excess body weight. The aim of the study was to evaluate the effect of laparoscopic sleeve gastrectomy (LSG) on morbid obesity and type 2 diabetes (T2DM) in the long-term follow-up.One hundred ninety-five obese patients, 78 with T2DM, were evaluated before and after LSG up to 10 years, to identify complete diabetes remission (FPG < 100 mg/dl, A1c < 6.0%), partial remission (FPG 100-125 mg/dl, A1c < 6.5%), or relapse.Before surgery, body weight and BMI were 123 ± 21 kg and 44.6 ± 6.8 kg/m2 respectively; at a mean follow-up of 7 years (range 4-10), body weight was 104.9 ± 18 kg and BMI 37 ± 6 kg/m2. Minimum weight was reached after 2 years. T2DM remission was observed in 66, 57, and 52% at short (< 2 years), medium (2-5 years), and long-term (> 5 years) follow-up respectively. Furthermore, 45.2% maintained complete remission for at least 5 years and about 36% showed a persistent but improved diabetes. None of the patients cured from diabetes had a duration disease greater than 8 years and a glycemic control requiring insulin. The prevalence of hypertension and dyslipidemia significantly decreased from 49 to 35% and from 51 to 40% respectively.LSG significantly improves body weight, diabetes, hypertension, and dyslipidemia in long-term follow-up.