Reduction of Premature Aging Markers After Gastric Bypass Surgery in Morbidly Obese Patients

• DOI: 10.1007/s11695-018-3247-3
• Publication Date: 2018-04-24T18:03:41Z
• Authors: P. J. Hohensinner; C. Kaun; B. Ebenbauer; M. Hackl; S. Demyanets; D. Richter; M. Prager; J. Wojta; Gersina Rega-Kaun
• Keywords: Proinflammatory cytokine

Obesity is considered to be a major comorbidity. Obese patients suffer from an increased proinflammatory state associated with premature aging phenotype including secretion of senescence-associated secretory proteins (SASP) and reduced telomere length. Micro-ribonucleic acids (miRNAs) are non-coding RNA molecules that could modify the post-transcriptional process. Several studies have reported associations between miRNAs metabolic unhealthy conditions.To determine if bariatric surgery resulting weight loss reverse phenotype.We enrolled 58 morbidly obese undergoing surgery. Markers SASP IL-6, CRP PAI-1, 7 miRNAs, as well length oxidation in mononuclear cells were evaluated.Patients showed significant drop body mass index (BMI; 43.98 ± 3.5 versus 28.02 4.1, p < 0.001). We observed reduction 55% plasma IL-6 levels (p = 0 0.001), 83% 0.001) 15% PAI-1 Telomere doubled patient cohort was accompanied by 70% inversely correlated oxidation. The aging-associated miRNA miR10a_5p upregulated significantly 0.039), while other tested no difference.Our data indicate after increase oxidative stress at telomeres. which downregulated during Overall, ameliorated phenotype.