Early predictors of in-hospital mortality in patients with COVID-19 in a large American cohort

• DOI: 10.1007/s11739-020-02509-7
• Publication Date: 2020-09-24T11:03:41Z
• Authors: Amit Bahl; Morgan Nees Van B...; Laura Ortiz; Nai-Wei Chen; Courtney Todd; Merit Milad; Alex Yang; Jonathan Tang; Madalyn Nygren; Lihua Qu
• Keywords: Procalcitonin

Coronavirus disease (COVID-19) has aggressively spread across the United States with numerous fatalities. Risk factors for mortality are poorly described. This was a multicentered cohort study identifying patient characteristics and diagnostic markers present on initial evaluation associated in hospitalized COVID-19 patients. Epidemiological, demographic, clinical, laboratory of survivors non-survivors were obtained from electronic medical records multivariable survival regression analysis conducted to identify risk in-hospital death. Of 1629 consecutive adult patients confirmed March 1st thru 31, 2020, 1461 included final analysis. 327 died during hospitalization 1134 survived discharge. Median age 62 years (IQR 50.0, 74.0) 56% under 65. 47% female 63% identified as African American. Most (55%) had either no or one comorbidity. In analysis, older age, admission respiratory status including elevated rate oxygen saturation ≤ 88%, derangements creatinine > 1.33 mg/dL, alanine aminotransferase 40 U/L, procalcitonin 0.5 ng/mL, lactic acid ≥ 2 mmol/L increased is largest analyses an epicenter pandemic. Older low admission, lab renal hepatic dysfunction These can help clinicians prognosticate should be considered management strategies.