Lipid Abnormalities in a Never‐Treated HIV‐1 Subtype C‐Infected African Population

• DOI: 10.1007/s11745-009-3369-4
• Publication Date: 2009-11-14T13:17:27Z
• Authors: Carla Maria T. Fo...; Johannes M. Van R...; Annamarie Kruger; Aletta E. Schutte
• Keywords: Dyslipidemia

Abstract Dyslipidemia has been documented worldwide among human immunodeficiency virus‐infected (HIV) individuals and these changes are reminiscent of the metabolic syndrome (MetS). In South Africa, with highest number HIV infections worldwide, HIV‐1 subtype C is prevalent, while B (genetically different from C) prevails in Europe United States. We aimed to evaluate if infection (subtype associated dyslipidemia, inflammation occurrence MetS Africans. Three hundred newly diagnosed HIV‐infected participants were compared 300 age, gender, body mass index locality matched uninfected controls. was defined according Adult Treatment Panel III (ATP III) International Diabetes Federation (IDF) criteria. The group showed lower high density lipoprotein cholesterol (1.23 vs. 1.70 mmol/L) low (2.60 2.80 higher triglycerides (1.29 1.15 mmol/L), C‐reactive protein (3.31 2.13 mg/L) interleukin 6 (4.70 3.72 pg/L) levels group. No difference prevalence seen between two groups III, 15.2 11.5%; IDF, 21.1 22.6%). This study shows that but not a incidence never antiretroviral‐treated