Late-onset vascular complications of radiotherapy for primary brain tumors: a case–control and cross-sectional analysis

• DOI: 10.1007/s11764-023-01350-z
• Publication Date: 2023-05-05T03:27:53Z
• Authors: María-José Ibáñez...; Alberto Picca; Delphine Leclercq; Giulia Berzero; Julian Jacob; Loïc Feuvret; Charlotte Rosso; Cristina Birzu; Agusti Alentorn; Marc Sanson; Camille Tafani; Flavie Bompaire; Luis Bataller; Khê Hoang-Xuan; Jean-Yves Delattre; Dimitri Psimaras; Damien Ricard
• Keywords: Stroke; Cross-sectional study

Abstract Purpose Radiotherapy (RT) is a recognized risk factor for cerebrovascular (CV) disease in children and adults with head neck cancer. We aimed to investigate whether cerebral RT increases the of CV primary brain tumors (PBT). Methods retrospectively identified supratentorial PBT diagnosed between 1975 2006 at least 10 years follow-up after treatment. analyzed demographic, clinical, radiological features special attention events. also described events, vascular factors, intracranial artery modifications cross-sectional study irradiated patients alive time study. Results A total 116 patients, treated (exposed group), 85 non-irradiated (unexposed group) were enrolled. Stroke was more frequent than unexposed group (42/116 (36%) vs 7/85 (8%); p < 0.001), higher prevalence both ischemic (27/116 (23%) 6/85 (7%); = 0.004) hemorrhagic (12/116 (10%) 1/85 (1%); 0.02) stroke. In group, near Willis Polygon likely experience stroke ( 0.016). Fourty-four included this subgroup, arterial stenosis prevalent (11/45, 24%) compared general population (9%). Conclusions increased long-surviving cranial RT. Implications cancer survivors events are long propose check list guide management late complications PBT.